ECDYSTEROID Ở THỰC VẬT VÀ ĐA DẠNG CÁC LOÀI THỰC VẬT CHỨA ECDYSTEROID

Lê Xuân Đắc1, Vũ Thị Loan2
1 Viện Sinh thái nhiệt đới, Trung tâm Nhiệt đới Việt - Nga
2 Viện Y sinh nhiệt đới, Trung tâm Nhiệt đới Việt - Nga

Nội dung chính của bài viết

Tóm tắt

ECDYSTEROIDS IN PLANTS AND DIVERSITY OF SPECIES CONTAINNING ECDYSTEROID

Ecdysteroids are steroidal hormones that have been originally found in the animal kingdom to control moulting (ecdysis) and other metamorphosic processes in insects. Structurally, they are polyhydroxylated compounds that have a four-ringed skeleton, usually composed of 27, 28 or 29 carbon atoms. This group of naturally occurring plant ecdysteroids was designated phytoecdysteroids (Pes) to differentiate them from those isolated from animal sources. Recently more and more researchs have focused, on the effects of Pes on vertebrates and humans. The range of effects of these compounds appears to be very wide. They are apparently nontoxic to mammals, most of them are useful for humans. They have a broad spectrum of pharmacological and medicinal properties in mammals, including hepatoprotective and hypoglycaemic effects, increase adaptation and anabolic effects, without androgenic side-effects. Pes are also being considered as nutraceutical additives to food products.

Since the first discovery, 503 ecdysteroid compounds have been detected in 1339 species belong to 132 terrestrial plant families. Phytoecdysteroids have been detected from seeds, fruits, flowers, anthers, leaves, hark, stems, roots… The distribution of Pes in plant depends mainly on organs, the stage of development and the position of the organ on the plant, and can undergo changes depending on the season or geographical location.

Chi tiết bài viết

Tài liệu tham khảo

1. Bộ Tài nguyên và Môi trường, Tài liệu đào tạo, tập huấn về tiếp cận nguồn gen và chia sẻ lợi ích từ việc sử dụng nguồn gen, Bộ Tài nguyên và Môi trường, Hà Nội, 2014.
2. Nguyễn Thị Thanh Bình, Mai Văn Trì, Nguyễn Văn Hùng, Nguyễn Thành Minh, Tách chiết ecdysteroid từ phân tằm, Tạp chí Sinh học, 1999, 21(2):52-54.
3. Nguyễn Thị Thanh Bình, Đào Đình Cường, Nguyễn Văn Hùng, Mai Văn Trì, Kết quả kiểm tra hoạt tính sinh học của hợp chất chứa ecdysteroid được tách chiết từ lá dâu Morus alba L., Tạp chí Sinh học, 1998, 20(1):57-59.
4. Nguyễn Văn Hùng, Nghiên cứu thành phần hóa học và hoạt tính sinh học cây Lược vàng (Calisia fragrans), Báo cáo Đề tài cấp Nhà nước, Viện Hàn lâm Khoa học và Công nghệ Việt Nam, Hà Nội, 2014.
5. Trịnh Thị Thủy, Trần Văn, Sung, Guenter, Adam, Nghiên cứu thành phần hóa học cây Bình linh cọng mảnh (Vitex leptobotrys), Tạp chí Hóa học, 2000, 38(2):1-7.
6. Володин В.В., Володинa С.О., Ву Тхи Лоан, Фам Хак Линь, Методология изучения распространения Экдистероидов в мировой флоре. Первичные результаты скрининга флоры Вьетнама, Tạp chí Khoa học và Công nghệ Nhiệt đới, 2016, 11:3-14.
7. Bandara B.M.R., Jayasinghe L., Karunaratne V., Wannigama G.P., Bokel M., Kraus W., Sotheeswaran S., Ecdysterone from stem of Diploclisia glaucescens, Phytochemistry, 1989, 28:1073-1075.
8. Baltaev U.A., Phytoecdysteroids: Structure, sources, and biosynthesis in plants, Russ J Bioorg Chem, 2000, 26(12):799-831.
9. Bathori M., Toth N., Hunyadi A., Marki A., Zador E., Phytoecdysteroids and anabolic-androgenic steroids, Structure and effects on humans, Curr Med Chem, 2008, 15:75-91.
10. Budesinsky M., Voka K., Harmatha J., Cvacka J., Additional minor ecdysteroid components of Leuzea carthamoides, Steroids, 2008, 73:502-514.
11. Butenandt A., Karlson P., Uber die Isolierung eines Metamorphose-hormons der Insekten in kristallisierter Form, Z Naturforsch, 1954, 9B:389-391.
12. Dat Le Duc, Ngoc Ninh Thi, Tu Vu Anh, Diep Chau Ngoc, Thao Nguyen Phuong, Anh Hoang Le Tuan, Nam Nguyen Hoai, Cuong Nguyen Xuan, Vy Nguyen Tuong, Kim Young Ho, Ban Ninh Khac, Kiem Phan Van, Minh Chau Van, Ecdysteroid from Achyranthes bidentata, VN J Chem, 2012, 50(5A):254-258.
13. Dinan L., Phytoecdysteroids: biological aspects, Phytochemistry, 2001, 57:325-339.
14. Dinan L., Ecdysteroid structure-activity relationships, In: Natural products chemistry, bioactive natural products (Part J) (Ed. Atta-ur-Rahman), Elsevier Scientific, Amsterdam, The Netherlands, 2003, 29:3-71.
15. Dinan L., The Karlson lecture, Phytoecdysteroids: what use are they? Arch Insect Biochem Physiol, 2009, 72:126-141.
16. Dittrich M., Solich P., Opletal L., Hunt A.J., Smart J.D., 20-Hydroxyecdysone release from biodegradable devices: the effect of size and shape, Drug Dev Ind Pharm, 2000, 26(12):1285-1291.
17. Gao L., Cai G., Shi X., Beta-ecdysterone induces osteogenic differentiation in mouse mesenchymal stem cells and relieves osteoporosis, Biol Pharm Bull, 2008, 31(12):2245-2249.
18. Golovatskaya I.F., Effect of ecdysterone on morphological and physiological processes in plants, Russ J Plant Physiol, 2004, 51:407-413.
19. Grebenok R.J., Venkatachari S., Adler J.H., Biosynthesis of ecdysone and ecdysone phosphates in spinach, Phytochemistry, 1994, 36:1399-1408.
20. Hilaly J.E., Lyoussi B., Hypoglycaemic effect of the lyophilised aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats, J Ethnopharm, 2002, 80(2-3):109-113.
21. Hsieh C.W., Cheng J.Y., Wang T.H., Wang H.J., Ho W.J., Hypoglycaemic effects of Ajuga extract in vitro and in vivo, J Funct Food, 2014, 6:224-230.
22. Kholodova Y.D, Phytoecdysteroids: biological effects, application in agriculture and complementary medicine, Ukr Biokhim Zh, 2001, 73:21-29.
23. Kizelsztein P., Govorko D., Komarnytsky S., Evans A., Wang Z., Cefalu W. T., Raskin I., 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model, Am J Physiol Endocrinol Metab, 2009, 296(3):433-439.
24. Lafont R., Ecdysteroids and related molecules in animals and plants, Arch Insect Biochem Physiol, 1997, 35:3-20.
25. Lafont R., Phytoecdysteroids in the world flora: diversity, distribution, biosynthesis and evolution, Russ J Plant Physiol, 1998, 45:276-295.
26. Lafont R., Dinan L., Practical uses for ecdysteroids in mammals including humans: an update, Journal of Insect Science 3:7, Available online: insectscience.org/3.7, 2003.
27. Lafont R., Dinan L., Ecdysone; Structures and function, Springer, 2009, tr. 551-578
28. Lafont R., Harmatha J., Marion-Poll F., Dinan L., Wilson I. D., The Ecdysone Handbook, 3rd edition, Date of last update: 20/04/2017, on-line: http://ecdybase.org, 2017.
29. Lafont R., Horn D.H.S., Phytoecdysteroids: structures and occurrence, In: Ecdysone, from Chemistry to Mode of Action (Ed. Koolman J), Georg Thieme Verlag, Stuttgart, 1989, tr. 39-64.
30. Machackova I., Vagner M., Slama K., Comparison between the effects of 20-hydroxyecdysone and phytohormones on growth and development in plants, Eur J Entomol, 1995, 92:309-316.
31. Ramazanov N.S., Phytoecdysteroids and other biologically active compounds from plants of the genus Ajuga, Chem Nat Comp, 2005, 41(4):361-369.
32. Taleb S.D., Ghomari H., Krouf D., Bouderbala S., Prost J., Lacaille M.A., Bouchenak M., Antioxidant effect of Ajuga iva aqueous extract in streptozotocin-induced diabetic rats, Phytomedicine, 2009, 16(6-7):623-631.
33. Tarkowska D., Strnad M., Plant ecdysteroids: plant sterols with intriguing distributions, biological effects and relations to plant hormones, Planta, 2016, 244:545-555.