HIỆU LỰC TÁC DỤNG CỦA CHẾ PHẨM THUỐC TIÊM FENTANYL NGHIÊN CỨU BÀO CHẾ TRONG NƯỚC
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STUDY ON EFFICACY OF DOMESTICALLY STUDIED AND MANUFACTURED FENTANYL CITRATE INJECTION
This paper presents the evaluation of efficacy of domestically studied and manufactured fentanyl injections on experimented animals. Fentanyl citrate injections (ampoules of 500 μg, 10ml) of Roxtemedica Company (Germany) are used as the reference drug. Analgesic effect is studied on the mice by hot plate induced pain model and acetic acid induced "writhing test". The product is applied in the surgical practices on dogs (involved 10 types of surgery). The parameters such as heart rate, respiration rate, blood pressure and volume of used fentanyl citrate injection (mL; mL/min; mL/min.kg) are recorded. The study results show that fentanyl citrate have strong analgesic and anesthesic effects. The studied injection is completly effective when used for anesthesia and analgesia in surgical practice. Fentanyl citrate does not cause contractions on bronchus smooth muscle of guinea pig. All the results show that the fentanyl injections have equivalent effects as the reference drug.
Từ khóa
Fentanyl citrate injection, efficacy, anesthesia time, thuốc tiêm fentanyl, fentanyl injections
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Tài liệu tham khảo
2. Phạm Duy Nam, Thái Am, Vương Văn Trường, Bùi Thị Hồng Phương, Tổng hợp fentanyl citrat (FC) dùng làm thuốc gây mê giảm đau trong và sau phẫu thuật, Tạp chí Kiểm nghiệm thuốc, số 3A, 2008, tr.68.
3. Vũ Mạnh Hùng, Lê Thị Hồng Hạnh, Phạm Duy Nam, Đánh giá độc tính cấp và độc tính bán trường diễn của chế phẩm thuốc tiêm fentanyl nghiên cứu bào chế trong nước, Tạp chí Khoa học và Công nghệ Nhiệt đới, số 3, 2013, tr.56 - 63.
4. Abraham W.B., Techniques of animal and clinical toxicology, Med. Pub., Chicago, 1978, p.55 - 68.
5. Turner A., Screening methods in pharmacology, Academic Press, NewYork and London, 1965, p.60 - 68.
6. Witkin, L.B., Heuter, C.F., Galdi, F., O'Keefe, E., Spitaletta, P., Plummer, A. J., Pharmacology of 2-amino-indane hydrocloride (Su-8629), a potent non- narcotic analgesic, The Journal of Pharmacology and Experimental Therapeutics, Vol.133, 1961, p.400 - 408.
7. Raymond M. Burgison, Animal techniques for evaluation anesthetic drugs, in book: Animal and Clinical techniques for evaluating drugs, 1967.
8. Gardocki J.F., John Yelnosky, Study of some of the pharmacologic Action of Fentanyl citrat. Toxicology and applied pharmacology, Vol.6, 1964, p.48 - 62.
9. Franzone J.S., Cirillo R. and Biffignandi P., Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF, Eur. J. Pharmacol., Vol.165, 1964, p.269 - 274.