NGHIÊN CỨU TÌNH HÌNH NHIỄM VI RÚT VIÊM GAN HBV, HCV, HDV VÀ ĐẶC ĐIỂM DI TRUYỀN PHÂN TỬ CỦA HBV TRÊN ĐỐI TƯỢNG THANH NIÊN Ở HAI TỈNH THÁI NGUYÊN, ĐÀ NẴNG CỦA VIỆT NAM

Tóm tắt

INVESTIGATION OF HBV, HCV, HDV INFECTION PREVALENCE AND MOLECULAR GENETIC CHARACTERISTICS OF HBV AMONG YOUNG ADULTS IN THAI NGUYEN, DA NANG IN VIETNAM

Hepatitis B (HBV), C (HCV), and D (HDV) are common infectious diseases that cause serious health consequences and lead to death due to dangerous complications such as acute liver failure, cirrhosis, and liver cancer. According to The World Health Organization estimates, there were about 354 cases of chronic HBV and HCV infection in 2019. Vietnam is a country that has high rates of HBV infection and an estimated 8.6 million people are infected with HBV. In this study, we identified the prevalence rates of HBV, HCV, and HDV in 1248 serum samples collected from healthy among young adults aged 18 to 29 years old (mean age: 20.3 ± 1, 4) in Thai Nguyen and Da Nang in 2018 by ELISA. We also identified the HBV genotype in HBV-DNA-positive samples, sequenced the preS/S gene, and analyzed the phylogenetic tree. The study result showed that the detection rate of HBsAg antigen is 3.5% and total anti-HBc is 24.9%, the detection rate of anti-HCV is low and the anti-HDV is not decided in the cohort of (18-29 years old) young adults in Thai Nguyen and Da Nang. The phylogenetic analysis showed there is a circulating of genotype B and genotype C. The rate of HBV belonging to the B4 subtype is 78.9% and belonging to the C1 subtype is only 21.1%. 15/19 samples of recombinant HBV detected is the genotype B4/C. The rare mutant G145K belonging to a vaccine escape mutation is identified in one of the HBV samples in Thai Nguyen; the core promoter double mutation A1762T/G1762A are identified in one of the HBV sample; and only one mutation A1762T is identified in one of the HBV sample.