KẾT HỢP LIỆU PHÁP OXY CAO ÁP TRONG ĐIỀU TRỊ LOÉT DA, NIÊM MẠC DO BIẾN CHỨNG MUỘN SAU XẠ TRỊ Ở BỆNH NHÂN UNG THƯ VÙNG ĐẦU, CỔ

Phạm Thị Duyên1, , Nguyễn Phương Nam1, Trần Thị Hằng1
1 Chi nhánh Phía Nam, Trung tâm Nhiệt đới Việt - Nga
Tác giả liên hệ:
Phạm Thị Duyên
Chi nhánh Phía Nam, Trung tâm Nhiệt đới Việt - Nga
Số 3 đường 3/2 phường 11 Quận 10, Tp. Hồ Chí Minh
Số điện thoại: 0986249296;  Email: bsduyen.0975@gmail.com

Nội dung chính của bài viết

Tóm tắt

STUDY ON THE EFFECTS OF COMBINED HYPERBARIC OXYGEN  THERAPY IN THE TREATMENT OF SKIN AND MUCOSAL ULCERS  CAUSED BY LATE COMPLICATIONS AFTER RADIATION THERAPY IN PATIENTS WITH HEAD AND NECK CANCER

This article presents the results of the study "Study on the effects of combined hyperbaric oxygen therapy in the treatment of skin and mucosal ulcers caused by late complications after radiation therapy in patients with head and neck cancer" in order to determine the ratio ulcer improvement in this patient group.

The study was conducted at High pressure oxygen Center (Southern Branch of  Joint Vietnam - Russia Tropical Science and Technology Research Center) from June 2020 to May 2022, with 90 patients diagnosed with mucous and skin ulcers because of complications after radiotherapy of head and neck cancer, divided into 2 groups of 60 patients in the treatment group and 30 patients in the control group.

Research results show that: the level of congestion, swelling, exudate at the ulcer improved significantly, the largest reduction is the day 20th of treatment  onwards. The highest level of functional symptom improvement is pain relief reaching 100%, ranging from little pain relief to great pain relief; restricted mouth opening 97.1%; difficulty swallowing 97.4%; difficulty speaking 92.6%; difficulty turning 92.9 and dry mouth 91.7%. The overall ulcer improvement rate of patients after treatment increased gradually with the number of hours of HBOT treatment, on day 10, 20, 30, the rate was good and decreased by 18.3% and 58.3%, respectively; 71.7% and 20%; 6.5% and 6.7%; and especially 23.3% of patients recovered.

Chi tiết bài viết

Tài liệu tham khảo

1. Nguyễn Chấn Hùng,Ung bướu học nội khoa, NXBY học, 2004, tr. 194-206.
2. Nguyễn Thị Thu Hương, yhoccongdong.com/thongtin/nhung-net-chinh-ve-ung-thu-vung-dau-co/, July 9, 2014.
3. Nguyễn Sào Trung, “Bướu của đường hô hấp tiêu hóa trên”, Bệnh học ung bướu cơ bản, Trung tâm đào tạo và bồi dưỡng cán bộ y tế TP HCM, 1992, tr.29-44.
4. Davis J. C., Dunn J. M., Gates G. A., Heimbach R. D., Hyperbaric oxygen: a new adjunct in the management of radiation necrosis, Arch Otolaryngol, 1979, 105:58-61.
5. Filntisis G. A., Moon R. E., Kraft K. L., Farmer J. C., Scher R. L., Piantadosi C. A., Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18
cases and review of the literature, 2000 Jun, 109(6):554-62.
6. Henk J. M., Kunkler P. B., Smith C. W., Radiotherapy and hyperbaric oxygen in head and neck cancer: final report of first controlled clinical trial, Lancet, 1977, 2(8029):101-103.
7. Kaur S., Pawar M., Banerjee N., Garg R., Evaluation of the efficacy of hyperbaric oxygen therapy in the management of chronic nonhealing ulcer and role of periwound transcutaneous oximetry as a predictor of wound healing response: a randomized prospective controlled trial, J. Anaesthesiol. Clin. Pharmacol., 2012, 28:70-5.
8. Marx R. E., Ehler W. J., Tayapongsak P., Pierce L. W., Relationship of oxygen dose to angiogenesis induction in irradiated tissue, Am. J. Surg., 2010, 160:519-24.
9. Mechine A., Rohr S., Toti F., et al., “Wound healing and hyperbaric oxygen. Experimental study of the angiogenesis phase in the rate”, Ann. Chir., 1999, 53(4):307-313.
10. Narozny W., Sicko Z., Kot J., Stankiewicz C., Przewozny T., Kuczkowski J., Hyperbaric oxygen therapy in the treatment of complications of irradiation in head and neck area, Undersea Hyperb. Med., 2005 Mar-Apr, 32(2):103-10.
11. Puneet Gupta, Tarun Sahni G. K., Jadhav, Sapna Manocha, Shweta Aggarwal, Sapna Verma, A retrospective study of outcomes in subjects of head and neck cancer treated with hyperbaric oxygen therapy for radiation induced osteoradionecrosis of mandible at a tertiary care centre: An indian experience, Indian J. Otolaryngol. Head Neck Surg., July 2013, 65(1):140-143.
12. Sarbjot Kaur, Mridula Pawar, Neerja Banerjee, and Rakesh Garg, Evaluation of the efficacy of hyperbaric oxygen therapy in the management of chronic nonhealing ulcer and role of periwound transcutaneous oximetry as a predictor of wound healing response: A randomized prospective controlled trial, J. Anaesthesiol. Clin. Pharmacol., 2012 Jan-Mar, 28(1):70-75.
13. Chuan F., Tang K., Jiang P., Zhou B., He X., Reliability and validity of the perfusion, extent, depth, infection and sensation (PEDIS) classification system and score in patients with diabetic foot ulcer, PloS one, 2015, 10(4):e0124739.