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Ngày nhận bài: 01/08/2022
Ngày sửa đổi: 22/09/2022
Ngày chấp nhận: 31/10/2022
Ngày xuất bản: 23/04/2025
Ngày xuất bản Online: 30/03/2025
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DOI: https://doi.org/10.58334/vrtc.jtst.n29.12
Số xuất bản
Số 29 (2022)
Chuyên mục
NGHIÊN CỨU KHOA HỌC CÔNG NGHỆ
Trích dẫn bài báo
Pham, V. C., Ngo, V. H., Ngo, V. D., Vu, T. T., Do, T. T. H., Do, T. T., Nguyen, T. T. H., Pham, N. T., Nguyen, T. A., Cu, L. H., & Hoang, L. T. A. (2025). CHEMICAL CONSTITUENTS FROM THE ARIAL OF Crinum asiaticum L. Tạp chí Khoa học và Công nghệ nhiệt đới, 29, 121-129. https://doi.org/10.58334/vrtc.jtst.n29.12

CHEMICAL CONSTITUENTS FROM THE ARIAL OF Crinum asiaticum L.

Pham Van Cong1, Ngo Van Hieu1, Ngo Viet Duc1, Vu Thi Trang1, Do Thi Thu Hien1, Do Thanh Tuan2, Nguyen Thi Thu Hien3, Pham Ngoc Thuat4, Nguyen Tuan Anh5, Cu Lan Huong5, Hoang Le Tuan Anh1,
1 Centre for Research and Technology Transfer
2 Thaibinh University of Medicine and Pharmacy
3 Hanoi University of Mining and Geology
4 Institute of Technology - General Department for Defence Industry
5 Central Ethnic Minority College Preparatory School
Tác giả liên hệ:
Hoang Le Tuan Anh
Centre for Research and Technology Transfer
18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam
Số điện thoại: 84-948151838;  Email: hltanh@ctctt.vast.vn

Nội dung chính của bài viết

Tóm tắt

Crinum asiaticum L. (locally known Nang hoa trang), belonging to the Crinum genus of the Amaryllidaceae family, has been widely used in oriental and traditional medicine around the world for the treatment of various diseases and exerts diverse promising pharmacological effects. To find out new inhibitors for the treatment of inflammatory and Alzheimer’s diseases, a methanol extract of the aerial part of C. asiaticum was investigated to afford six compounds, chrysophanol (1), emodin (2), physcion (3), thymine (4), thymidine (5), and 5-(hydroxymethyl)-2-furfural (6) by using various chromatographic separations. Their structures were identified by the extensive analysis of 1H- and 13C-NMR data as well as a comparison with those of previously reported data. This is the first report of these compounds (1-6) from C. asiaticum. In addition, all compounds evaluated the inhibitory activities of NO production and acetylcholinesterase (AChE). Among them, emodin (2) significantly inhibited NO production with an IC50 of 5.13±0.42 μM. This result indicated that emodin (2) may be beneficial in the treatment of anti-inflammatory diseases. Besides, all compounds (1-6) also showed weak inhibitory effects on the AChE enzyme with a range of IC50 values from 82.98±9.19 to 237.63±13.8 µM.

Từ khóa

Crinum asiaticum L., anti-inflammation, acetylcholinesterase (AChE), kháng viêm

Chi tiết bài viết

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